The present study deals with the application of heterogeneous photocatalysis in pilot compound parabolic solar (CPC) reactor for the advanced treatment of hospital secondary wastewater effluent treatment using TiO2 and g-C3N4 catalysts. Degradation followed first order kinetics with the corresponding rates ranging from 0.018 and 0.013 LkJ-1 for citalopram and O-des-Venlafaxine to 0.039 and 0.044 LkJ-1 for venlafaxine and amisulpride, respectively. The treatment was followed also by EEM-fluorescence as well as toxicity (Microtox) and risk assessment.