This study investigates the optimization of cadmium (Cd) removal from wastewater using the electrocoagulation (EC) process coupled with Response Surface Methodology (RSM). Synthetic wastewater containing 100 mg/L of Cd²⁺ was treated in a laboratory-scale reactor using aluminum and iron electrodes. Key operational parameters such as pH (4-10), current density (30-90 A/m²) and reaction time (20-60 min) were studied to investigate their influence on cadmium removal efficiency by Box-Behnken design. Cd removal efficiency ranged from 85.8-99.2% with better efficiency at neutral to slightly alkaline conditions. Statistical analysis indicated that pH was the most significant factor affecting removal efficiency followed by reaction time and current density had a minor effect. The quadratic model developed was found to be highly significant (p < 0.0001) with high coefficient of determination (R² = 0.992) and non-significant lack-of-fit confirming its reliability. The optimum conditions were found to be pH 8.8, current density 68.5 A/m² and reaction time 40.5 min which predicted a removal efficiency of 99.49%. Experimental validation showed removal efficiency of 97.64% with only 1.85% deviation. The results obtained suggest that EC combined with RSM is an effective and promising method for the cadmium removal from wastewater.