Chlorination is effective in inactivating microorganisms. However, its interaction with natural organic matter (NOM) and inorganic ions leads to the formation of disinfection byproducts (DBPs). Surrogate parameters, such as the differential absorbance at 272 nm (DA272), have shown potential for monitoring NOM degradation and DBP formation. This study aims to evaluate the applicability of DA272 as a control tool for both microbial inactivation and DBP control. The results demonstrate a strong correlation between DA272 and the microbial inactivation ratio and suggest that specific DA272 thresholds can be established to ensure both effective disinfection and DBP control within the treatment plant.