Effective flood management requires the priori assessment of the flood event, its consequences, and thus its risk, which give insight into what situations we expect and allow us to evaluate possible measures, including the implementation of an Early Warning System. In the present work, we briefly describe a methodology for flood risk assessment at town scale, which combines the typical hazard assessment via hydrodynamic calculations using the 1D/2D HEC-RAS model, with a rather original procedure for vulnerability assessment on a building level. We apply this high-resolution methodology at a part of the town Mandra to show that the buildings with the highest flood risk are located along Koropouli Street; these are the buildings that suffered the highest damages during the disastrous flood of November 2017.