Sediment cores of 4m were sampled in Epanoni coastal lagoon basin in Eastern Thermaikos Gulf. Within this study, we present results of Magnetic Susceptibility (MS) measurements and sedimentological analysis (XRD and grain-size distribution) for the first meter EP1-1 aiming to contribute to the reconstruction of the paleoclimatic regime in Thermaikos Gulf during the Holocene. Based on MS and XRD, we concluded that probably a wet episode is reflected at 3760±25 BP resulting in greater material transfer with higher values of magnetic susceptibility. The increased ratio of the coarser sediments in depths 40-50cm suggests an increased run-off. Subsequently that, the presence of gypsum in the upper layers of 14-39cm depth indicates a dry period with intense evaporation.