Seaport infrastructure monitoring promotes the development of an effective management system that ensures functionality, structural capacity and safety. Monitoring approaches are considered to be a useful tool in an attempt to deal with growing global trends, such as seaport “smartness”, or with challenging issues such as climate crisis, while enhancing the financial performance and the capability of a seaport to remain competitive in the trading environment. Therefore, the present paper proposes a framework for integrating monitoring processes and relevant data analyses to improve seaport smartness and adaptive capacity to climate change. The framework is applied at the seaport of Lavrio, located in central-eastern Greece, where in-situ inspection and condition assessment is performed through utilizing modern monitoring techniques. The research outlines the significance of establishing a robust monitoring system such as the one hereto described to minimize the impact of natural hazards, perform suitable maintenance strategies and optimize the required periodic control of seaport facilities.