Daily flow-proportional composite influent wastewater was collected from the Wastewater Treatment Plant (WWTP) in Athens during a nine-year sampling campaign (2010-2019). Analytes in influent wastewater are markers of the consumption and the exposure of the chemicals in the population. Wastewater samples were cleaned up and enriched 200 times using a generic solid phase extraction protocol based on a mixture of four sorbent materials capable of retaining a wide-range of analytes. Extracts were analyzed by a wide-scope targeted LC-QTOFMS and by highly-sensitive LC-MS/MS methods for the determination of pharmaceuticals such as antidepressants, anxiolytics, antipsychotics, antibiotics, antiepileptics, analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics, antihypertensives, antiulcer, and steroids as well as the main illicit drugs and their metabolites among others. Furthermore, the daily consumption of the substances was back-calculated with the aim of revealing trends in the use patterns of the compounds and associate the changes with socioeconomic phenomena, law enforcements and financial indicators.