The present paper focuses on the development of a methodology that simulates micrometeorological thermal conditions in an urban context based on weather station data. The micrometeorological conditions at Syntagma square, the central square of Athens, Greece were simulated by ENVI-met software in order to evaluate the thermal conditions experienced by its users. Located in the heart of city’s commercial activity, the square attracts many visitors, especially during summer months, when extreme thermal conditions could be encountered. ENVI-met can simulate the necessary factors for the estimation of thermal sensation through thermal indices, i.e. air temperature, mean radiant temperature, relative humidity, and wind speed. The meteorological data needed as input were obtained from the nearest weather station. In-situ micrometeorological measurements recorded at the height of 1.1m, were used to validate the simulated results. ENVI-met simulations were performed at a high spatial and temporal resolution. The appropriate adjustments were made to the modeling procedure to achieve a successful and resource-effective simulation.